<i>Supt16</i> Haploinsufficiency Impairs PI3K/AKT/mTOR/Autophagy Pathway in Human Pluripotent Stem Cells Derived Neural Stem Cells

<i>Supt16</i> Haploinsufficiency Impairs PI3K/AKT/mTOR/Autophagy Pathway in Human Pluripotent Stem Cells Derived Neural Stem Cells

The maintenance of neural stem cells (NSCs) plays a critical role in neurodevelopment and has been implicated in neurodevelopmental disorders (NDDs). However, the underlying mechanisms linking defective human neural stem cell self-renewal to NDDs remain undetermined. Our previous study found that &l...

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Bibliographic Details
Main Authors: Junwen Wang, Ziyi Wang, Limeng Dai, Xintong Zhu, Xingying Guan, Junyi Wang, Jia Li, Mao Zhang, Yun Bai, Hong Guo
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
neurodevelopmental disorders (NDDs)
<i>Supt16</i>
human neural stem cells (hNSCs)
proliferation
autophagy
Online Access:https://www.mdpi.com/1422-0067/24/3/3035

Internet

https://www.mdpi.com/1422-0067/24/3/3035

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