Vav proteins do not influence dengue virus replication but are associated with induction of phospho-ERK, IL-6, and viperin mRNA following DENV infection in vitro

Vav proteins do not influence dengue virus replication but are associated with induction of phospho-ERK, IL-6, and viperin mRNA following DENV infection in vitro

ABSTRACT Vav proteins are guanine exchange factors that activate Rac1/RhoA signaling to regulate many biological processes including inflammatory responses. Here, the expression and functional significance of Vav’s were investigated during dengue virus (DENV) infection. In primary monocyte-derived m...

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Bibliographic Details
Main Authors: Evangeline Cowell, Hawraa Jaber, Luke P. Kris, Madeleine G. Fitzgerald, Valeria M. Sanders, Aidan J. Norbury, Nicholas S. Eyre, Jillian M. Carr
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:Microbiology Spectrum
Subjects:
dengue virus
Vav
inflammation
azathioprine
interleukin-6
viperin
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02391-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.02391-23

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