Development of a rapid GC-FID method to simultaneously determine triethylamine, diisopropylamine, and 1,1,3,3-tetramethylguanidine residues in an active pharmaceutical ingredient

Development of a rapid GC-FID method to simultaneously determine triethylamine, diisopropylamine, and 1,1,3,3-tetramethylguanidine residues in an active pharmaceutical ingredient

A rapid GC-FID method was developed to simultaneously determine residual levels of triethylamine (TEA), 1,1,3,3-tetramethylguanidine (TMG), and diisopropylamine (DIPA) in the synthetic route of an active pharmaceutical ingredient (API). Due to the severe absorption of amines on GC stationary phases,...

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Bibliographic Details
Main Authors: Minshan Shou, Haixiao Qiu
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Journal of Pharmaceutical Analysis
Subjects:
GC-FID
Amines
API
Method development
Method qualification
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177919310809

Internet

http://www.sciencedirect.com/science/article/pii/S2095177919310809

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