Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells

Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells

We report that a major subpopulation of monocyte-derived macrophages (MDMs) contains high levels of dUTP, which is incorporated into HIV-1 DNA during reverse transcription (U/A pairs), resulting in pre-integration restriction and post-integration mutagenesis. After entering the nucleus, uracilated v...

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Bibliographic Details
Main Authors: Erik C Hansen, Monica Ransom, Jay R Hesselberth, Nina N Hosmane, Adam A Capoferri, Katherine M Bruner, Ross A Pollack, Hao Zhang, Michael Bradley Drummond, Janet M Siliciano, Robert Siliciano, James T Stivers
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-09-01
Series:eLife
Subjects:
U/A DNA base pairs in HIV
uracil base excision repair
latency in macrophages
viral restriction
Online Access:https://elifesciences.org/articles/18447

Internet

https://elifesciences.org/articles/18447

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