An empirical comparison of the harmful effects for randomized controlled trials and non-randomized studies of interventions

Introduction: Randomized controlled trials (RCTs) are the gold standard to evaluate the efficacy of interventions (e.g., drugs and vaccines), yet the sample size of RCTs is often limited for safety assessment. Non-randomized studies of interventions (NRSIs) had been proposed as an important alternat...

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Bibliographic Details
Main Authors: Minhan Dai, Luis Furuya-Kanamori, Asma Syed, Lifeng Lin, Qiang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1064567/full