Lipid–Polymer Hybrid Nanoparticles for mRNA Delivery to Dendritic Cells: Impact of Lipid Composition on Performance in Different Media

To combine the excellent transfection properties of lipids with the high stability of polymeric nanoparticles, we designed a hybrid system with a polymeric core surrounded by a shell of different lipids. The aim is to use this technology for skin vaccination purposes where the transfection of dendri...

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Bibliographic Details
Main Authors: Lena Kliesch, Simon Delandre, Aljoscha Gabelmann, Marcus Koch, Kai Schulze, Carlos A. Guzmán, Brigitta Loretz, Claus-Michael Lehr
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceutics
Subjects:
Online Access:https://www.mdpi.com/1999-4923/14/12/2675