Expression of the Circadian Clock Gene BMAL1 Positively Correlates With Antitumor Immunity and Patient Survival in Metastatic Melanoma

Expression of the Circadian Clock Gene BMAL1 Positively Correlates With Antitumor Immunity and Patient Survival in Metastatic Melanoma

IntroductionMelanoma is the most lethal type of skin cancer, with increasing incidence and mortality rates worldwide. Multiple studies have demonstrated a link between cancer development/progression and circadian disruption; however, the complex role of tumor-autonomous molecular clocks remains poor...

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Bibliographic Details
Main Authors: Leonardo Vinícius Monteiro de Assis, Gabriela Sarti Kinker, Maria Nathália Moraes, Regina P. Markus, Pedro Augusto Fernandes, Ana Maria de Lauro Castrucci
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Oncology
Subjects:
skin cancer
melanoma
circadian rhythms
clock genes
ARNTL/BMAL1 immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00185/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2018.00185/full

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