Inhibition of RhoA/Rho-kinase pathway suppresses the expression of extracellular matrix induced by CTGF or TGF- β in ARPE-19

Inhibition of RhoA/Rho-kinase pathway suppresses the expression of extracellular matrix induced by CTGF or TGF- β in ARPE-19

<b>AIM:</b> To investigate the role of Rho-associated protein kinase (ROCK) inhibitor, Y27632, in mediating the production of extracellular matrix (ECM) components including fibronectin, matrix metallo-proteinase-2 (MMP-2) and type I collagen as induced by connective tissue growth facto...

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Bibliographic Details
Main Author: Jing Zhu
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2013-02-01
Series:International Journal of Ophthalmology
Subjects:
Rho-associated protein kinase inhibitor
Connective tissue growth factor
transforming growth factor-β
proliferative vitreoretinopathy
Online Access:http://www.ncbi.nlm.nih.gov/pmc/issues/219982/

Internet

http://www.ncbi.nlm.nih.gov/pmc/issues/219982/

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