Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing

Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing

Keratinocytes, the predominant cell type of the epidermis, migrate to reinstate the epithelial barrier during wound healing. Mechanical cues are known to regulate keratinocyte re-epithelialization and wound healing; however, the underlying molecular transducers and biophysical mechanisms remain elus...

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Bibliographic Details
Main Authors: Jesse R Holt, Wei-Zheng Zeng, Elizabeth L Evans, Seung-Hyun Woo, Shang Ma, Hamid Abuwarda, Meaghan Loud, Ardem Patapoutian, Medha M Pathak
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Series:eLife
Subjects:
mechanotransduction
mechanically activated ion channels
ion channel dynamics
cellular retraction
collective migration
cell migration
Online Access:https://elifesciences.org/articles/65415

Internet

https://elifesciences.org/articles/65415

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