Mitochondrial-Targeted Antioxidant Maintains Blood Flow, Mitochondrial Function, and Redox Balance in Old Mice Following Prolonged Limb Ischemia

Mitochondrial-Targeted Antioxidant Maintains Blood Flow, Mitochondrial Function, and Redox Balance in Old Mice Following Prolonged Limb Ischemia

Aging is a major factor in the decline of limb blood flow with ischemia. However, the underlying mechanism remains unclear. We investigated the role of mitochondrial reactive oxygen species (ROS) with regard to limb perfusion recovery in aging during ischemia. We performed femoral artery ligation in...

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Bibliographic Details
Main Authors: Shunsuke Miura, Shu-ichi Saitoh, Tomoki Kokubun, Takashi Owada, Hiroyuki Yamauchi, Hirofumi Machii, Yasuchika Takeishi
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:International Journal of Molecular Sciences
Subjects:
oxidative stress
angiogenesis
mitochondria
ischemia
p53
proliferator-activated receptor γ coactivator-1α (PGC-1α)
aging
Online Access:https://www.mdpi.com/1422-0067/18/9/1897

Internet

https://www.mdpi.com/1422-0067/18/9/1897

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