Activating mutations in JAK2 and CALR differentially affect intracellular calcium flux in store operated calcium entry

Activating mutations in JAK2 and CALR differentially affect intracellular calcium flux in store operated calcium entry

Abstract Background Calcium (Ca2+) signaling regulates various vital cellular functions, including integrin activation and cell migration. Store-operated calcium entry (SOCE) via calcium release-activated calcium (CRAC) channels represents a major pathway for Ca2+ influx from the extracellular space...

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Bibliographic Details
Main Authors: Vikas Bhuria, Tobias Franz, Conny Baldauf, Martin Böttcher, Nicolas Chatain, Steffen Koschmieder, Tim H. Brümmendorf, Dimitrios Mougiakakos, Burkhart Schraven, Sascha Kahlfuß, Thomas Fischer
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Cell Communication and Signaling
Subjects:
Calcium flux
EPO signaling
TPO signaling
MPNs
JAK2-V617F
CALR mutation
Online Access:https://doi.org/10.1186/s12964-024-01530-z

Internet

https://doi.org/10.1186/s12964-024-01530-z

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