Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures

Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures

Cyclic nucleotide-modulated channels have important roles in visual signal transduction and pacemaking. Binding of cyclic nucleotides (cAMP/cGMP) elicits diverse functional responses in different channels within the family despite their high sequence and structure homology. The molecular mechanisms...

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Bibliographic Details
Main Authors: Jan Rheinberger, Xiaolong Gao, Philipp AM Schmidpeter, Crina M Nimigean
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
cyclic nucleotide-gated ion channel
lipid nanodisc
cryo-electron microscopy
single-channel recording
partial agonism
allostery
Online Access:https://elifesciences.org/articles/39775

Internet

https://elifesciences.org/articles/39775

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