PURPL represses autophagic cell death to promote cutaneous melanoma by modulating ULK1 phosphorylation

PURPL represses autophagic cell death to promote cutaneous melanoma by modulating ULK1 phosphorylation

Abstract Uncontrolled overactivation of autophagy may lead to autophagic cell death, suppression of which is a pro-survival strategy for tumors. However, mechanisms involving key regulators in modulating autophagic cell death remain poorly defined. Here, we report a novel long noncoding RNA, p53 upr...

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Bibliographic Details
Main Authors: Shuo Han, Xue Li, Ke Wang, Dingheng Zhu, Bingyao Meng, Jieyu Liu, Xiaoting Liang, Yi Jin, Xingyuan Liu, Qian Wen, Liang Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2021-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04362-8

Internet

https://doi.org/10.1038/s41419-021-04362-8

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