Relationship between Altered miRNA Expression and DNA Methylation of the DLK1-DIO3 Region in Azacitidine-Treated Patients with Myelodysplastic Syndromes and Acute Myeloid Leukemia with Myelodysplasia-Related Changes

Relationship between Altered miRNA Expression and DNA Methylation of the DLK1-DIO3 Region in Azacitidine-Treated Patients with Myelodysplastic Syndromes and Acute Myeloid Leukemia with Myelodysplasia-Related Changes

The DLK1–DIO3 region contains a large miRNA cluster, the overexpression of which has previously been associated with myelodysplastic syndromes (MDS). To reveal whether this overexpression is epigenetically regulated, we performed an integrative analysis of miRNA/mRNA expression and DNA met...

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Bibliographic Details
Main Authors: Michaela Dostalova Merkerova, Hana Remesova, Zdenek Krejcik, Nikoleta Loudova, Andrea Hrustincova, Katarina Szikszai, Jaroslav Cermak, Anna Jonasova, Monika Belickova
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cells
Subjects:
microRNA
myelodysplastic syndromes
acute myeloid leukemia
azacitidine
14q32
MEG3
Online Access:http://www.mdpi.com/2073-4409/7/9/138

Internet

http://www.mdpi.com/2073-4409/7/9/138

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