Galunisertib enhances chimeric antigen receptor-modified T cell function

Galunisertib enhances chimeric antigen receptor-modified T cell function

Chimeric antigen receptor (CAR) T cell therapy still faces the challenge of immunosuppression when treating solid tumors. TGF-β is one of the critical factors in the tumor microenvironment to help tumors escape surveillance by the immune system. Here we tried using the combination of a small molecul...

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Bibliographic Details
Main Authors: Zhixiong Wang, Qian Liu, Na Risu, Jiayu Fu, Yan Zou, Jiaxing Tang, Long Li, Hui Liu, Guomin Zhou, Xuekai Zhu
Format: Article
Language:English
Published: PAGEPress Publications 2020-06-01
Series:European Journal of Histochemistry
Subjects:
CAR T
TGF-β
solid tumor
immunotherapy
immunosuppression
Online Access:https://www.ejh.it/index.php/ejh/article/view/3122

Internet

https://www.ejh.it/index.php/ejh/article/view/3122

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