Non-Glycosylated SARS-CoV-2 Omicron BA.5 Receptor Binding Domain (RBD) with a Native-like Conformation Induces a Robust Immune Response with Potent Neutralization in a Mouse Model

Non-Glycosylated SARS-CoV-2 Omicron BA.5 Receptor Binding Domain (RBD) with a Native-like Conformation Induces a Robust Immune Response with Potent Neutralization in a Mouse Model

The Omicron BA.5 variant of SARS-CoV-2 is known for its high transmissibility and its capacity to evade immunity provided by vaccine protection against the (original) Wuhan strain. In our prior research, we successfully produced the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein in an...

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Bibliographic Details
Main Authors: Rawiwan Wongnak, Subbaian Brindha, Mami Oba, Takahiro Yoshizue, Md. Din Islam, M. Monirul Islam, Hitoshi Takemae, Tetsuya Mizutani, Yutaka Kuroda
Format: Article
Language:English
Published: MDPI AG 2024-06-01
Series:Molecules
Subjects:
Omicron SARS-CoV-2
neutralization
non-glycosylation
molten globule state
native-like state
immunogenicity
Online Access:https://www.mdpi.com/1420-3049/29/11/2676

Internet

https://www.mdpi.com/1420-3049/29/11/2676

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