Loss of photoreceptorness and gain of genomic alterations in retinoblastoma reveal tumor progression

Loss of photoreceptorness and gain of genomic alterations in retinoblastoma reveal tumor progression

Background: Retinoblastoma is a pediatric eye cancer associated with RB1 loss or MYCN amplification (RB1+/+MYCNA). There are controversies concerning the existence of molecular subtypes within RB1−/− retinoblastoma. To test whether these molecular subtypes exist, we performed molecular profiling. Me...

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Bibliographic Details
Main Authors: Irsan E. Kooi, Berber M. Mol, Annette C. Moll, Paul van der Valk, Marcus C. de Jong, Pim de Graaf, Saskia E. van Mil, Antoinette Y.N. Schouten-van Meeteren, Hanne Meijers-Heijboer, Gertjan L. Kaspers, Hein te Riele, Jacqueline Cloos, Josephine C. Dorsman
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:EBioMedicine
Subjects:
Retinoblastoma
Retina
Pediatric oncology
Cancer
Expression profiling
Progression
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415300499

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http://www.sciencedirect.com/science/article/pii/S2352396415300499

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