Enriched enrollment randomized double-blind placebo-controlled cross-over trial with phenytoin cream in painful chronic idiopathic axonal polyneuropathy (EPHENE): a study protocol

Enriched enrollment randomized double-blind placebo-controlled cross-over trial with phenytoin cream in painful chronic idiopathic axonal polyneuropathy (EPHENE): a study protocol

Abstract Background Patients with chronic idiopathic axonal polyneuropathy (CIAP) can have neuropathic pain that significantly impacts quality of life. Oral neuropathic pain medication often has insufficient pain relief and side effects. Topical phenytoin cream could circumvent these limitations. Th...

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Bibliographic Details
Main Authors: David J. Kopsky, Ruben P. A. van Eijk, Janna K. Warendorf, Jan M. Keppel Hesselink, Nicolette C. Notermans, Alexander F. J. E. Vrancken
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Trials
Subjects:
Polyneuropathy
Neuropathic pain
Phenytoin
Cream
Topical
Randomized study
Online Access:https://doi.org/10.1186/s13063-022-06806-8

Internet

https://doi.org/10.1186/s13063-022-06806-8

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