Effects of bone morphogenetic protein 4 on TGF-β1-induced cell proliferation, apoptosis, activation and differentiation in mouse lung fibroblasts via ERK/p38 MAPK signaling pathway

Effects of bone morphogenetic protein 4 on TGF-β1-induced cell proliferation, apoptosis, activation and differentiation in mouse lung fibroblasts via ERK/p38 MAPK signaling pathway

Fibroblasts, in particular myofibroblasts, are the critical effector cells in idiopathic pulmonary fibrosis (IPF), a deadly lung disease characterized by abnormal lung remodeling and the formation of “fibroblastic foci”. Aberrant activation of TGF-β1 is frequently encountered and promotes fibroblast...

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Bibliographic Details
Main Authors: Zhou Cai, Hua Guo, Jing Qian, Wei Liu, Yuanyuan Li, Liang Yuan, You Zhou, Ran Lin, Xiaohui Xie, Qiong Yang, Guoying Wu, Qiongqiong Li, Li Zhao, Fei Liu, Jian Wang, Wenju Lu
Format: Article
Language:English
Published: PeerJ Inc. 2022-07-01
Series:PeerJ
Subjects:
Pulmonary fibrosis
BMP4
TGF-β1
Fibroblasts
Activation
Apoptosis
Online Access:https://peerj.com/articles/13775.pdf

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https://peerj.com/articles/13775.pdf

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