VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway

VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway

Summary: von Hippel-Lindau (VHL), known as a tumor suppressor gene, is frequently mutated in clear cell renal cell carcinoma (ccRCC). However, VHL mutation is not sufficient to promote tumor formation. In most cases other than ccRCC, VHL loss alters cellular homeostasis and causes cell stress and me...

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Bibliographic Details
Main Authors: Meng Jiao, Mengjie Hu, Dong Pan, Xinjian Liu, Xuhui Bao, Jonathan Kim, Fang Li, Chuan-Yuan Li
Format: Article
Language:English
Published: Elsevier 2024-07-01
Series:iScience
Subjects:
Molecular biology
Immunity
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224015104

Internet

http://www.sciencedirect.com/science/article/pii/S2589004224015104

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