Self-attention enabled deep learning of dihydrouridine (D) modification on mRNAs unveiled a distinct sequence signature from tRNAs

Self-attention enabled deep learning of dihydrouridine (D) modification on mRNAs unveiled a distinct sequence signature from tRNAs

Dihydrouridine (D) is a modified pyrimidine nucleotide universally found in viral, prokaryotic, and eukaryotic species. It serves as a metabolic modulator for various pathological conditions, and its elevated levels in tumors are associated with a series of cancers. Precise identification of D sites...

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Bibliographic Details
Main Authors: Yue Wang, Xuan Wang, Xiaodong Cui, Jia Meng, Rong Rong
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: bioinformatics
dihydrouridine
CNN
local self-attention
RNA modification
sequence-derived features
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123000173

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http://www.sciencedirect.com/science/article/pii/S2162253123000173

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