Inhibition of the Growth of Breast Cancer-Associated Brain Tumors by the Osteocyte-Derived Conditioned Medium

Inhibition of the Growth of Breast Cancer-Associated Brain Tumors by the Osteocyte-Derived Conditioned Medium

The brain is a common site of metastasis from advanced breast cancer but few effective treatments are available. We examined a therapeutic option with a conditioned medium (CM), focusing on the role of Lrp5 and β-catenin in Wnt signaling, and IL1ra in osteocytes. Osteocytes presented the innate anti...

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Bibliographic Details
Main Authors: Tomohiko Sano, Xun Sun, Yan Feng, Shengzhi Liu, Misato Hase, Yao Fan, Rongrong Zha, Di Wu, Uma K. Aryal, Bai-Yan Li, Akihiro Sudo, Hiroki Yokota
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
breast cancer
osteocytes
conditioned medium
Lrp5
β-catenin
IL1ra
Online Access:https://www.mdpi.com/2072-6694/13/5/1061

Internet

https://www.mdpi.com/2072-6694/13/5/1061

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