A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling

A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling

Alterations in both the expression and function of the non-receptor tyrosine kinase Zap70 are associated with numerous human diseases including immunodeficiency, autoimmunity, and leukemia. Zap70 propagates the TCR signal by phosphorylating two important adaptor molecules, LAT and SLP76, which orche...

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Detaylı Bibliyografya
Asıl Yazarlar: Annika Schultz, Marvin Schnurra, Ali El-Bizri, Nadine M. Woessner, Sara Hartmann, Roland Hartig, Susana Minguet, Burkhart Schraven, Luca Simeoni
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: MDPI AG 2022-09-01
Seri Bilgileri:Cells
Konular:
Zap70
TCR-ζ
TCR signaling
C564
Lck
T-cell activation
Online Erişim:https://www.mdpi.com/2073-4409/11/17/2723

Internet

https://www.mdpi.com/2073-4409/11/17/2723

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