Synthesis, X-ray Single-Crystal Analysis, and Anticancer Activity Evaluation of New Alkylsulfanyl-Pyridazino[4,5-b]indole Compounds as Multitarget Inhibitors of EGFR and Its Downstream PI3K-AKT Pathway

Synthesis, X-ray Single-Crystal Analysis, and Anticancer Activity Evaluation of New Alkylsulfanyl-Pyridazino[4,5-b]indole Compounds as Multitarget Inhibitors of EGFR and Its Downstream PI3K-AKT Pathway

The alkylation of 3,5-dihydro-4H-pyridazino[4,5-b]indole-4-thione with benzyl bromide, ethyl chloroacetate, and allyl bromide in the presence of potassium carbonate (K<sub>2</sub>CO<sub>3</sub>) yielded new alkylsulfanylpyridazino[4,5-b]indole derivatives (i.e., compounds <...

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Bibliographic Details
Main Authors: Eid E. Salama, Ibrahim O. Althobaiti, Matti Haukka, Ahmed T. A. Boraei
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Crystals
Subjects:
pyridazino[4,5-b]indole
alkylation
anticancer activity
X-ray single crystal
Online Access:https://www.mdpi.com/2073-4352/12/3/353

Internet

https://www.mdpi.com/2073-4352/12/3/353

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