Evolutionary history of disease‐susceptibility loci identified in longitudinal exome‐wide association studies

Evolutionary history of disease‐susceptibility loci identified in longitudinal exome‐wide association studies

Abstract Background Our longitudinal exome‐wide association studies previously detected various genetic determinants of complex disorders using ~26,000 single‐nucleotide polymorphisms (SNPs) that passed quality control and longitudinal medical examination data (mean follow‐up period, 5 years) in 488...

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Bibliographic Details
Main Authors: Yoshiki Yasukochi, Jun Sakuma, Ichiro Takeuchi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Yoshiji Yamada
Format: Article
Language:English
Published: Wiley 2019-09-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
extended haplotype homozygosity
linkage disequilibrium
longitudinal exome‐wide association study
positive selection
single‐nucleotide polymorphism
Online Access:https://doi.org/10.1002/mgg3.925

Internet

https://doi.org/10.1002/mgg3.925

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