H2-Driven Reduction of Flavin by Hydrogenase Enables Cleaner Operation of Nitroreductases for Nitro-Group to Amine Reductions

H2-Driven Reduction of Flavin by Hydrogenase Enables Cleaner Operation of Nitroreductases for Nitro-Group to Amine Reductions

Hydrogenase-mediated reduction of flavin mononucleotide by H2 is exploited to enable cleaner application of nitroreductase enzymes for reduction of aromatic nitro functional groups. This turns the overall reaction into a biocatalytic hydrogenation. Use of flavin-containing nitroreductases in industr...

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Bibliographic Details
Main Authors: Miguel A. Ramirez, Shiny Joseph Srinivasan, Sarah E. Cleary, Peter M. T. Todd, Holly A. Reeve, Kylie A. Vincent
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Catalysis
Subjects:
biocatalytic hydrogenation
flavin recycling
nitro-reduction
hydrogenation
industrial biotechnology
nitroreductase
Online Access:https://www.frontiersin.org/articles/10.3389/fctls.2022.906694/full

Internet

https://www.frontiersin.org/articles/10.3389/fctls.2022.906694/full

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