H2-Driven Reduction of Flavin by Hydrogenase Enables Cleaner Operation of Nitroreductases for Nitro-Group to Amine Reductions
Hydrogenase-mediated reduction of flavin mononucleotide by H2 is exploited to enable cleaner application of nitroreductase enzymes for reduction of aromatic nitro functional groups. This turns the overall reaction into a biocatalytic hydrogenation. Use of flavin-containing nitroreductases in industr...
Main Authors: | Miguel A. Ramirez, Shiny Joseph Srinivasan, Sarah E. Cleary, Peter M. T. Todd, Holly A. Reeve, Kylie A. Vincent |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-06-01
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Series: | Frontiers in Catalysis |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fctls.2022.906694/full |
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