HDAC4 mutant represses chondrocyte hypertrophy by locating in the nucleus and attenuates disease progression of posttraumatic osteoarthritis

HDAC4 mutant represses chondrocyte hypertrophy by locating in the nucleus and attenuates disease progression of posttraumatic osteoarthritis

Abstract Background The aim of this study was to evaluate whether histone deacetylase 4 S246/467/632A mutant (m-HDAC4) has enhanced function at histone deacetylase 4 (HDAC4) to attenuate cartilage degeneration in a rat model of osteoarthritis (OA). Methods Chondrocytes were infected with Ad-m-HDAC4-...

Descrizione completa

Dettagli Bibliografici
Autori principali: Xiaodong Gu, Fei Li, Yangyang Gao, Xianda Che, Pengcui Li
Natura: Articolo
Lingua:English
Pubblicazione: BMC 2022-01-01
Serie:BMC Musculoskeletal Disorders
Soggetti:
Histone deacetylase 4 S246/467/632A mutant
Chondrocyte hypertrophy
Nucleus translocation
Osteoarthritis
Accesso online:https://doi.org/10.1186/s12891-021-04947-6

Accesso online

https://doi.org/10.1186/s12891-021-04947-6

Documenti analoghi