HDAC4 mutant represses chondrocyte hypertrophy by locating in the nucleus and attenuates disease progression of posttraumatic osteoarthritis

HDAC4 mutant represses chondrocyte hypertrophy by locating in the nucleus and attenuates disease progression of posttraumatic osteoarthritis

Abstract Background The aim of this study was to evaluate whether histone deacetylase 4 S246/467/632A mutant (m-HDAC4) has enhanced function at histone deacetylase 4 (HDAC4) to attenuate cartilage degeneration in a rat model of osteoarthritis (OA). Methods Chondrocytes were infected with Ad-m-HDAC4-...

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Bibliographic Details
Main Authors: Xiaodong Gu, Fei Li, Yangyang Gao, Xianda Che, Pengcui Li
Format: Article
Language:English
Published: BMC 2022-01-01
Series:BMC Musculoskeletal Disorders
Subjects:
Histone deacetylase 4 S246/467/632A mutant
Chondrocyte hypertrophy
Nucleus translocation
Osteoarthritis
Online Access:https://doi.org/10.1186/s12891-021-04947-6

Internet

https://doi.org/10.1186/s12891-021-04947-6

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