HDAC4 mutant represses chondrocyte hypertrophy by locating in the nucleus and attenuates disease progression of posttraumatic osteoarthritis

HDAC4 mutant represses chondrocyte hypertrophy by locating in the nucleus and attenuates disease progression of posttraumatic osteoarthritis

Abstract Background The aim of this study was to evaluate whether histone deacetylase 4 S246/467/632A mutant (m-HDAC4) has enhanced function at histone deacetylase 4 (HDAC4) to attenuate cartilage degeneration in a rat model of osteoarthritis (OA). Methods Chondrocytes were infected with Ad-m-HDAC4-...

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Bibliografiske detaljer
Main Authors:	Xiaodong Gu, Fei Li, Yangyang Gao, Xianda Che, Pengcui Li
Format:	Article
Sprog:	English
Udgivet:	BMC 2022-01-01
Serier:	BMC Musculoskeletal Disorders
Fag:	Histone deacetylase 4 S246/467/632A mutant Chondrocyte hypertrophy Nucleus translocation Osteoarthritis
Online adgang:	https://doi.org/10.1186/s12891-021-04947-6

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