HDAC4 mutant represses chondrocyte hypertrophy by locating in the nucleus and attenuates disease progression of posttraumatic osteoarthritis

HDAC4 mutant represses chondrocyte hypertrophy by locating in the nucleus and attenuates disease progression of posttraumatic osteoarthritis

Abstract Background The aim of this study was to evaluate whether histone deacetylase 4 S246/467/632A mutant (m-HDAC4) has enhanced function at histone deacetylase 4 (HDAC4) to attenuate cartilage degeneration in a rat model of osteoarthritis (OA). Methods Chondrocytes were infected with Ad-m-HDAC4-...

Полное описание

Библиографические подробности
Главные авторы:	Xiaodong Gu, Fei Li, Yangyang Gao, Xianda Che, Pengcui Li
Формат:	Статья
Язык:	English
Опубликовано:	BMC 2022-01-01
Серии:	BMC Musculoskeletal Disorders
Предметы:	Histone deacetylase 4 S246/467/632A mutant Chondrocyte hypertrophy Nucleus translocation Osteoarthritis
Online-ссылка:	https://doi.org/10.1186/s12891-021-04947-6

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