Survival of Surfactant Protein-A1 and SP-A2 Transgenic Mice After Klebsiella pneumoniae Infection, Exhibits Sex-, Gene-, and Variant Specific Differences; Treatment With Surfactant Protein Improves Survival

Survival of Surfactant Protein-A1 and SP-A2 Transgenic Mice After Klebsiella pneumoniae Infection, Exhibits Sex-, Gene-, and Variant Specific Differences; Treatment With Surfactant Protein Improves Survival

Surfactant protein A (SP-A) is involved in lung innate host defense and surfactant-related functions. The human SFTPA1 and SFTPA2 genes encode SP-A1 and SP-2 proteins, and each gene has been identified with numerous genetic variants. SP-A1 and SP-A2 differentially enhance bacterial phagocytosis. Sex...

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Bibliographic Details
Main Authors: Nithyananda Thorenoor, Todd M. Umstead, Xuesheng Zhang, David S. Phelps, Joanna Floros
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
pulmonary surfactant protein A
pneumonia infection
surfactant protein A1 and A2
sex differences
innate host defense
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02404/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02404/full

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