The Late-Stage Protective Effect of Mito-TEMPO against Acetaminophen-Induced Hepatotoxicity in Mouse and Three-Dimensional Cell Culture Models

The Late-Stage Protective Effect of Mito-TEMPO against Acetaminophen-Induced Hepatotoxicity in Mouse and Three-Dimensional Cell Culture Models

An overdose of acetaminophen (APAP), the most common cause of acute liver injury, induces oxidative stress that subsequently causes mitochondrial impairment and hepatic necroptosis. N-acetyl-L-cysteine (NAC), the only recognized drug against APAP hepatotoxicity, is less effective the later it is adm...

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Bibliographic Details
Main Authors: Mohammad Abdullah-Al-Shoeb, Kenta Sasaki, Saori Kikutani, Nanami Namba, Keiichi Ueno, Yuki Kondo, Hitoshi Maeda, Toru Maruyama, Tetsumi Irie, Yoichi Ishitsuka
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Antioxidants
Subjects:
liver injury
acetaminophen
Mito-TEMPO
mitochondria
CCAAT/enhancer binding protein homologous protein
c-jun N-terminal kinases
Online Access:https://www.mdpi.com/2076-3921/9/10/965

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https://www.mdpi.com/2076-3921/9/10/965

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