Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution

Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution

Coactivator complexes SAGA and NuA4 stimulate transcription by post-translationally modifying chromatin. Both complexes contain the Tra1 subunit, a highly conserved 3744-residue protein from the Phosphoinositide 3-Kinase-related kinase (PIKK) family and a direct target for multiple sequence-specific...

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Bibliographic Details
Main Authors: Luis Miguel Díaz-Santín, Natasha Lukoyanova, Emir Aciyan, Alan CM Cheung
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
chromatin
transcription activation
coactivator
PIKK
SAGA
NuA4
Online Access:https://elifesciences.org/articles/28384

Internet

https://elifesciences.org/articles/28384

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