Heterogeneity of the Abnormal Prion Protein (PrPSc) of the Chandler Scrapie Strain

Heterogeneity of the Abnormal Prion Protein (PrPSc) of the Chandler Scrapie Strain

The pathological prion protein, PrPSc, displays various sizes of aggregates. In this study, we investigated the conformation, aggregation stability and proteinase K (PK)-sensitivity of small and large PrPSc aggregates of mouse-adapted prion strains. We showed that small PrPSc aggregates, previously...

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Bibliographic Details
Main Authors: Takashi Yokoyama, Shirou Mohri, Morikazu Imamura, Yoshifumi Iwamaru, Kentaro Masujin, Kazuo Kasai
Format: Article
Language:English
Published: MDPI AG 2013-02-01
Series:Pathogens
Subjects:
prion
Chandler
small PrPSc aggregate
conformational stability
PK sensitivity
Online Access:http://www.mdpi.com/2076-0817/2/1/92

Internet

http://www.mdpi.com/2076-0817/2/1/92

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