Loss of phosphoserine polar group asymmetry and inhibition of cholesterol transport in Jurkat cells treated with cholesterylphosphoserine

Loss of phosphoserine polar group asymmetry and inhibition of cholesterol transport in Jurkat cells treated with cholesterylphosphoserine

Cholesterylphosphoserine (CPHS) is a synthetic ester of cholesterol showing immunosuppressive activity. In the present study, we have used the T cell line Jurkat to investigate its mechanism of action. CPHS incorporates into cells reaching a molar ratio of 0.23 and 3.9 with the total phospholipid an...

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Bibliographic Details
Main Authors: Federico Cusinato, Walter Habeler, Francesca Calderazzo, Francesca Nardi, Alessandro Bruni
Format: Article
Language:English
Published: Elsevier 1998-09-01
Series:Journal of Lipid Research
Subjects:
progesterone
sphingolipid-based domains
caveolae
phospholipid asymmetry
annexin V
cholesterol transport
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520321726

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http://www.sciencedirect.com/science/article/pii/S0022227520321726

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