Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes

Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes

The link between changes in astrocyte function and the pathological progression of Alzheimer's disease (AD) has attracted considerable attention. Interestingly, activated astrocytes in AD show abnormalities in their lipid content and metabolism. In particular, the expression of apolipoprotein E...

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Bibliographic Details
Main Authors: Masato Komai, Yuka Noda, Atsuya Ikeda, Nanaka Kaneshiro, Yuji Kamikubo, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Journal of Lipid Research
Subjects:
alzheimer’s disease
apolipoproteins
nuclear receptors/RXR
transcription
sphingosine phosphate
astrocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227524000154

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http://www.sciencedirect.com/science/article/pii/S0022227524000154

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