Mouse Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2α Axis

Mouse Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2α Axis

ABSTRACT The integrated stress response (ISR) is a cellular response system activated upon different types of stresses, including viral infection, to restore cellular homeostasis. However, many viruses manipulate this response for their own advantage. In this study, we investigated the association b...

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Bibliographic Details
Main Authors: Svenja Fritzlar, Turgut E. Aktepe, Yi-Wei Chao, Nathan D. Kenney, Michael R. McAllaster, Craig B. Wilen, Peter A. White, Jason M. Mackenzie
Format: Article
Language:English
Published: American Society for Microbiology 2019-06-01
Series:mBio
Subjects:
integrated stress response
mouse norovirus
protein kinase R
protein translation
stress granules
eIF2α
Online Access:https://journals.asm.org/doi/10.1128/mBio.00960-19

Internet

https://journals.asm.org/doi/10.1128/mBio.00960-19

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