Screening aptamers for 5-hydroxytryptamine receptor and its anti-depressant function

Screening aptamers for 5-hydroxytryptamine receptor and its anti-depressant function

Objective To explore the potential anti-depression effect of the screened nucleic acid aptamers via blocking 5-HT re-uptake binding to the 5-HTR. Methods The mouse gene coding 5-HT1AR was cloned, constructed, and the recombinant 5-HT1AR was expressed and purified. The ssDNA aptamer that binds 5-HT1A...

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Bibliographic Details
Main Author: SHAO Zhi-ding, GAO Xue, REN Jing, TANG Xiao-lei
Format: Article
Language:zho
Published: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. 2022-10-01
Series:Jichu yixue yu linchuang
Subjects:
depression|5-htr|selective 5-htr re-uptake inhibitors|systematic evolution of ligands by exponential enrichment (selex)|aptamer
Online Access:http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-10-1514.pdf

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http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-10-1514.pdf

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