Deciphering the pathway-specific regulatory network for production of ten-membered enediyne Tiancimycins in Streptomyces sp. CB03234-S

Deciphering the pathway-specific regulatory network for production of ten-membered enediyne Tiancimycins in Streptomyces sp. CB03234-S

Abstract Background The anthraquinone-fused 10-membered enediynes (AFEs), represented by tiancimycins (TNMs), possess a unique structural feature and promising potentials as payloads of antitumor antibody–drug conjugates. Despite many efforts, the insufficient yields remain a practical challenge for...

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Bibliographic Details
Main Authors: Manxiang Zhu, Fan Zhang, Ting Gan, Jing Lin, Yanwen Duan, Xiangcheng Zhu
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Microbial Cell Factories
Subjects:
Anthraquinone-fused enediynes
Tiancimycins
Orphan two-component regulatory system
Pathway-specific cascade regulatory network
EMSA
qRT-PCR
Online Access:https://doi.org/10.1186/s12934-022-01916-z

Internet

https://doi.org/10.1186/s12934-022-01916-z

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