Tie2-mediated vascular remodeling by ferritin-based protein C nanoparticles confers antitumor and anti-metastatic activities

Tie2-mediated vascular remodeling by ferritin-based protein C nanoparticles confers antitumor and anti-metastatic activities

Abstract Background Conventional therapeutic approaches for tumor angiogenesis, which are primarily focused on the inhibition of active angiogenesis to starve cancerous cells, target the vascular endothelial growth factor signaling pathway. This aggravates hypoxia within the tumor core and ultimatel...

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Bibliographic Details
Main Authors: Young Sun Choi, Hyeonha Jang, Biki Gupta, Ji-Hak Jeong, Yun Ge, Chul Soon Yong, Jong Oh Kim, Jong-Sup Bae, Im-Sook Song, In-San Kim, You Mie Lee
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Journal of Hematology & Oncology
Subjects:
Antitumor immune response
EPCR
Ferritin-based protein C nanoparticles
Tie2
Vascular normalization
Online Access:http://link.springer.com/article/10.1186/s13045-020-00952-9

Internet

http://link.springer.com/article/10.1186/s13045-020-00952-9

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