Ras-Related Protein Rab-32 and Thrombospondin 1 Confer Resistance to the EGFR Tyrosine Kinase Inhibitor Osimertinib by Activating Focal Adhesion Kinase in Non-Small Cell Lung Cancer

Ras-Related Protein Rab-32 and Thrombospondin 1 Confer Resistance to the EGFR Tyrosine Kinase Inhibitor Osimertinib by Activating Focal Adhesion Kinase in Non-Small Cell Lung Cancer

Treatment with the tyrosine kinase inhibitor (TKI) osimertinib is the standard of care for non-small cell lung cancer (NSCLC) patients with activating mutations in the epidermal growth factor receptor (EGFR). Osimertinib is also used in T790M-positive NSCLC that may occur de novo or be acquired foll...

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Bibliographic Details
Main Authors: Zeinab Kosibaty, Odd Terje Brustugun, Inger Johanne Zwicky Eide, Georgios Tsakonas, Oscar Grundberg, Luigi De Petris, Marc McGowan, Per Hydbring, Simon Ekman
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cancers
Subjects:
non-small cell lung cancer
exosomal RNA
osimertinib
transcriptome
epidermal growth factor receptor
Ras-related protein Rab-32
Online Access:https://www.mdpi.com/2072-6694/14/14/3430

Internet

https://www.mdpi.com/2072-6694/14/14/3430

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