Different binding and pathogenic effect of neurofascin and contactin–1 autoantibodies in autoimmune nodopathies

Different binding and pathogenic effect of neurofascin and contactin–1 autoantibodies in autoimmune nodopathies

IntroductionIgG4 autoantibodies against paranodal proteins are known to induce acute-onset and often severe sensorimotor autoimmune neuropathies. How autoantibodies reach their antigens at the paranode in spite of the myelin barrier is still unclear.MethodsWe performed in vitro incubation experiment...

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Bibliographic Details
Main Authors: Katharina Hecker, Julia Grüner, Beate Hartmannsberger, Luise Appeltshauser, Carmen Villmann, Claudia Sommer, Kathrin Doppler
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
autoimmune nodopathy
IgG4
neurofascin
contactin
node of ranvier
inflammatory neuropathy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1189734/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1189734/full

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