Membrane-Targeting Perylenylethynylphenols Inactivate Medically Important Coronaviruses via the Singlet Oxygen Photogeneration Mechanism

Membrane-Targeting Perylenylethynylphenols Inactivate Medically Important Coronaviruses via the Singlet Oxygen Photogeneration Mechanism

Perylenylethynyl derivatives have been recognized as broad-spectrum antivirals that target the lipid envelope of enveloped viruses. In this study, we present novel perylenylethynylphenols that exhibit nanomolar or submicromolar antiviral activity against Severe Acute Respiratory Syndrome Coronavirus...

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Bibliographic Details
Main Authors: Kseniya A. Mariewskaya, Daniil A. Gvozdev, Alexey A. Chistov, Petra Straková, Ivana Huvarová, Pavel Svoboda, Jan Kotouček, Nikita M. Ivanov, Maxim S. Krasilnikov, Mikhail Y. Zhitlov, Alexandra M. Pak, Igor E. Mikhnovets, Timofei D. Nikitin, Vladimir A. Korshun, Vera A. Alferova, Josef Mašek, Daniel Růžek, Luděk Eyer, Alexey V. Ustinov
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Molecules
Subjects:
perylene
photosensitizers
antivirals
singlet oxygen
SARS-CoV-2
Online Access:https://www.mdpi.com/1420-3049/28/17/6278

Internet

https://www.mdpi.com/1420-3049/28/17/6278

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