Long-Term Blockade of Nociceptive Na<sub>v</sub>1.7 Channels Is Analgesic in Rat Models of Knee Arthritis

Long-Term Blockade of Nociceptive Na<sub>v</sub>1.7 Channels Is Analgesic in Rat Models of Knee Arthritis

The voltage gated sodium channels (Na<sub>v</sub>) 1.7, 1.8, and 1.9 are primarily located on nociceptors where they are involved in signalling neuropathic pain. This study examined the effect of Na<sub>v</sub>1.7 blockade on joint pain using either the small molecule inhibit...

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Bibliographic Details
Main Authors: Allison R. Reid, Patrice D. Côté, Jason J. McDougall
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Biomolecules
Subjects:
Arthritis
biologics
demyelination
neuropathic pain
voltage-gated sodium channels
Online Access:https://www.mdpi.com/2218-273X/12/11/1571

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