miR-100a-5p-enriched exosomes derived from mesenchymal stem cells enhance the anti-oxidant effect in a Parkinson’s disease model via regulation of Nox4/ROS/Nrf2 signaling

miR-100a-5p-enriched exosomes derived from mesenchymal stem cells enhance the anti-oxidant effect in a Parkinson’s disease model via regulation of Nox4/ROS/Nrf2 signaling

Abstract Background The pathogenesis of Parkinson's disease (PD) has not been fully elucidated, and there are no effective disease-modifying drugs for the treatment of PD. Mesenchymal stem cells have been used to treat several diseases, but are not readily available. Methods Here, we used pheno...

Full description

Bibliographic Details
Main Authors: Songzhe He, Qiongqiong Wang, Liankuai Chen, Yusheng Jason He, Xiaofang Wang, Shaogang Qu
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Translational Medicine
Subjects:
Parkinson's disease
Dopaminergic neuron
Mesenchymal stem cell
Exosomes
miR-100-5p
NOX4
Online Access:https://doi.org/10.1186/s12967-023-04638-x

Internet

https://doi.org/10.1186/s12967-023-04638-x

Similar Items