Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems

Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems

Abstract Filaments made of residues 120-254 of transmembrane protein 106B (TMEM106B) form in an age-dependent manner and can be extracted from the brains of neurologically normal individuals and those of subjects with a variety of neurodegenerative diseases. TMEM106B filament formation requires clea...

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Bibliographic Details
Main Authors: Mehtap Bacioglu, Manuel Schweighauser, Derrick Gray, Sofia Lövestam, Taxiarchis Katsinelos, Annelies Quaegebeur, John van Swieten, Zane Jaunmuktane, Stephen W. Davies, Sjors H. W. Scheres, Michel Goedert, Bernardino Ghetti, Maria Grazia Spillantini
Format: Article
Language:English
Published: BMC 2024-06-01
Series:Acta Neuropathologica Communications
Subjects:
TMEM106B filaments
Amyloid
Astrocytes
Vacuoles
Peripheral nervous system
Online Access:https://doi.org/10.1186/s40478-024-01813-z

Internet

https://doi.org/10.1186/s40478-024-01813-z

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