miR-873a-5p Targets A20 to Facilitate Morphine Tolerance in Mice

miR-873a-5p Targets A20 to Facilitate Morphine Tolerance in Mice

Long-term morphine administration leads to tolerance and a gradual reduction in analgesic potency. Noncoding microRNAs (miRNAs) modulate gene expression in a posttranscriptional manner, and their dysregulation causes various diseases. Emerging evidence suggests that miRNAs play a regulatory role in...

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Bibliographic Details
Main Authors: Jiangju Huang, Xia Liang, Jian Wang, Yan Kong, Zengli Zhang, Zhuofeng Ding, Zongbin Song, Qulian Guo, Wangyuan Zou
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Neuroscience
Subjects:
morphine tolerance
microRNA
miR-873a-5p
A20 (TNFAIP3)
NF-κB
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00347/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00347/full

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