New Evidence of the Importance of Weak Interactions in the Formation of PML-Bodies

New Evidence of the Importance of Weak Interactions in the Formation of PML-Bodies

In this work, we performed a comparative study of the formation of PML bodies by full-length PML isoforms and their C-terminal domains in the presence and absence of endogenous PML. Based on the analysis of the distribution of intrinsic disorder predisposition in the amino acid sequences of PML isof...

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Bibliographic Details
Main Authors: Alexander V. Fonin, Sergey A. Silonov, Anna S. Fefilova, Olesya V. Stepanenko, Anastasia A. Gavrilova, Alexey V. Petukhov, Anna E. Romanovich, Anna L. Modina, Tatiana S. Zueva, Evgeniy M. Nedelyaev, Nadejda M. Pleskach, Mirya L. Kuranova, Irina M. Kuznetsova, Vladimir N. Uversky, Konstantin K. Turoverov
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
membrane-less organelles (MLOs)
PML-bodies
promyelocytic leukemia protein (PML) isoforms
acute hydrogen peroxide-induced oxidative stress
fluorescence recovery after photobleaching (FRAP)
liquid–liquid phase separation (LLPS)
Online Access:https://www.mdpi.com/1422-0067/23/3/1613

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https://www.mdpi.com/1422-0067/23/3/1613

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