Nrf2 Plays a Protective Role Against Intravascular Hemolysis-Mediated Acute Kidney Injury

Nrf2 Plays a Protective Role Against Intravascular Hemolysis-Mediated Acute Kidney Injury

Massive intravascular hemolysis is associated with acute kidney injury (AKI). Nuclear factor erythroid-2-related factor 2 (Nrf2) plays a central role in the defense against oxidative stress by activating the expression of antioxidant proteins. We investigated the role of Nrf2 in intravascular hemoly...

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Bibliographic Details
Main Authors: Alfonso Rubio-Navarro, Cristina Vázquez-Carballo, Melania Guerrero-Hue, Cristina García-Caballero, Carmen Herencia, Eduardo Gutiérrez, Claudia Yuste, Ángel Sevillano, Manuel Praga, Javier Egea, Pablo Cannata, Isabel Cortegano, Belén de Andrés, María Luisa Gaspar, Susana Cadenas, Patrycja Michalska, Rafael León, Alberto Ortiz, Jesús Egido, Juan Antonio Moreno
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Pharmacology
Subjects:
intravascular hemolysis
hemoglobin
heme
Nrf2
oxidative stress
tubular injury
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00740/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00740/full

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