Sexually Dimorphic Effects of Histamine Degradation by Enteric Glial Histamine <i>N</i>-Methyltransferase (HNMT) on Visceral Hypersensitivity

Sexually Dimorphic Effects of Histamine Degradation by Enteric Glial Histamine <i>N</i>-Methyltransferase (HNMT) on Visceral Hypersensitivity

Histamine is a neuromodulator that affects gut motility and visceral sensitivity through intrinsic and extrinsic neural pathways, yet the mechanisms regulating histamine availability in these pathways remain poorly understood. Here, we show that enteric glia contribute to histamine clearance in the...

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Bibliographic Details
Main Authors: Jonathon L. McClain, Wilmarie Morales-Soto, Jacques Gonzales, Visha Parmar, Elena Y. Demireva, Brian D. Gulbransen
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Biomolecules
Subjects:
histamine <i>N</i>-methyltransferase (HNMT)
histamine
enteric glia
enteric nervous system
intestine
visceral pain
Online Access:https://www.mdpi.com/2218-273X/13/11/1651

Internet

https://www.mdpi.com/2218-273X/13/11/1651

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